Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 207335..207857 Replicon chromosome
Accession NZ_CP102716
Organism Lacticaseibacillus rhamnosus strain DM065

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag NHB23_RS00915 Protein ID WP_005687756.1
Coordinates 207335..207595 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag NHB23_RS00920 Protein ID WP_005687754.1
Coordinates 207588..207857 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB23_RS00890 (NHB23_000890) 202751..203392 + 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
NHB23_RS00895 (NHB23_000895) 203460..204239 + 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
NHB23_RS00900 (NHB23_000900) 204424..205311 + 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
NHB23_RS00905 (NHB23_000905) 205378..206199 - 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
NHB23_RS00910 (NHB23_000910) 206396..207124 + 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
NHB23_RS00915 (NHB23_000915) 207335..207595 - 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
NHB23_RS00920 (NHB23_000920) 207588..207857 - 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NHB23_RS00925 (NHB23_000925) 208483..209283 + 801 WP_005690776.1 SDR family oxidoreductase -
NHB23_RS00930 (NHB23_000930) 209310..211178 + 1869 WP_014571687.1 HTH domain-containing protein -
NHB23_RS00935 (NHB23_000935) 211179..211688 + 510 WP_049179682.1 transcriptional regulator GutM -
NHB23_RS00940 (NHB23_000940) 211701..212270 + 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T254064 WP_005687756.1 NZ_CP102716:c207595-207335 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT254064 WP_005687754.1 NZ_CP102716:c207857-207588 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References