Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3868671..3868929 Replicon chromosome
Accession NZ_CP102694
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NV952_RS18835 Protein ID WP_000809168.1
Coordinates 3868777..3868929 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3868671..3868728 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS18815 3863719..3865050 + 1332 Protein_3675 fimbria/pilus outer membrane usher protein -
NV952_RS18820 3865063..3866021 + 959 Protein_3676 fimbrial family protein -
NV952_RS18825 3866060..3866959 - 900 WP_001300855.1 transcriptional activator NhaR -
NV952_RS18830 3867025..3868191 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3868671..3868728 - 58 - - Antitoxin
NV952_RS18835 3868777..3868929 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NV952_RS18840 3869033..3870163 - 1131 WP_001118464.1 molecular chaperone DnaJ -
NV952_RS18845 3870252..3872168 - 1917 WP_000516131.1 molecular chaperone DnaK -
NV952_RS18850 3872545..3872949 + 405 WP_000843559.1 DUF2541 family protein -
NV952_RS18855 3872975..3873688 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T254046 WP_000809168.1 NZ_CP102694:3868777-3868929 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT254046 NZ_CP102694:c3868728-3868671 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References