Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 641932..642731 Replicon chromosome
Accession NZ_CP102694
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NV952_RS03135 Protein ID WP_000347251.1
Coordinates 641932..642396 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NV952_RS03140 Protein ID WP_001307405.1
Coordinates 642396..642731 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS03105 (636933) 636933..637367 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NV952_RS03110 (637385) 637385..638263 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NV952_RS03115 (638253) 638253..639032 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NV952_RS03120 (639043) 639043..639516 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NV952_RS03125 (639539) 639539..640819 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
NV952_RS03130 (641068) 641068..641877 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NV952_RS03135 (641932) 641932..642396 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NV952_RS03140 (642396) 642396..642731 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NV952_RS03145 (642880) 642880..644451 - 1572 WP_001273761.1 galactarate dehydratase -
NV952_RS03150 (644826) 644826..646160 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
NV952_RS03155 (646176) 646176..646946 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T254034 WP_000347251.1 NZ_CP102694:c642396-641932 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT254034 WP_001307405.1 NZ_CP102694:c642731-642396 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References