Detailed information of TA system TA025402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 28618..29130
• Replicon: chromosome
• Accession: NC_015678
• Organism: Streptococcus parasanguinis ATCC 15912

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I1ZKJ4
• Locus tag: HMPREF0833_RS00215
• Protein ID: WP_013903192.1
• Coordinates: 28876..29130 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HMPREF0833_RS00210
• Protein ID: WP_003014291.1
• Coordinates: 28618..28872 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0833_RS00175	23794..24105	+	312	WP_003005853.1	ribosome assembly RNA-binding protein YhbY	-
HMPREF0833_RS00180	24127..24759	+	633	WP_003012335.1	nicotinate-nucleotide adenylyltransferase	-
HMPREF0833_RS00185	24756..25352	+	597	WP_013903187.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
HMPREF0833_RS00190	25353..25853	+	501	WP_013903188.1	cysteine hydrolase	-
HMPREF0833_RS00195	25868..26221	+	354	WP_003014310.1	ribosome silencing factor	-
HMPREF0833_RS00200	26475..27284	+	810	WP_013903189.1	class I SAM-dependent methyltransferase	-
HMPREF0833_RS00205	27291..28385	+	1095	WP_013903190.1	nucleotidyltransferase	-
HMPREF0833_RS00210	28618..28872	+	255	WP_003014291.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HMPREF0833_RS00215	28876..29130	+	255	WP_013903192.1	Txe/YoeB family addiction module toxin	Toxin
HMPREF0833_RS00220	29305..30021	+	717	WP_003005873.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HMPREF0833_RS00225	30074..30400	-	327	WP_009732369.1	hypothetical protein	-
HMPREF0833_RS00230	30381..30752	-	372	WP_013903193.1	hypothetical protein	-
HMPREF0833_RS00235	30749..32161	-	1413	WP_013903194.1	Y-family DNA polymerase	-
HMPREF0833_RS00240	32164..32841	-	678	WP_013903195.1	XRE family transcriptional regulator	-
HMPREF0833_RS00245	33001..33993	+	993	WP_003014342.1	aspartate--ammonia ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10082.55 Da
• Isoelectric Point: 7.9789

>T25402 WP_013903192.1 NC_015678:28876-29130 [Streptococcus parasanguinis ATCC 15912]
MLLKFTEDAWKDYCYWQSQDKKTLKRINTLIKEIQRDPFAGIGKPEPLKYDFQGAWSRRIDAENRLIYMLDESGVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T25402 NC_015678:28876-29130 [Streptococcus parasanguinis ATCC 15912]
ATGTTACTCAAGTTTACAGAAGATGCCTGGAAGGATTATTGTTACTGGCAAAGTCAGGACAAAAAAACACTGAAGCGAAT
CAATACCCTTATCAAAGAGATCCAAAGGGACCCATTTGCAGGGATTGGTAAGCCTGAGCCTTTGAAATATGACTTTCAAG
GAGCATGGTCAAGACGGATTGATGCAGAGAATCGCCTGATTTATATGCTAGATGAGTCAGGTGTCGCTTTCCTCTCTTTT
AAAGATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9703.98 Da
• Isoelectric Point: 4.6768

>AT25402 WP_003014291.1 NC_015678:28618-28872 [Streptococcus parasanguinis ATCC 15912]
MEAVVYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVISKSEWDSLQETLRLAQNKELSDKVLRGMAEVRAGQVQLH
EIEG

Nucleotide

• Length: 255 bp

>AT25402 NC_015678:28618-28872 [Streptococcus parasanguinis ATCC 15912]
ATGGAAGCAGTCGTTTATTCAACATTCCGCAATCATTTGAAGGATTATATGAAGAAGGTGAATGATGAGTTTGAGCCTTT
GACAGTCGTGAATAAGAATCCAGACGAAGATATTGTGGTCATCTCTAAGAGCGAGTGGGACAGCCTACAAGAAACCCTGA
GACTAGCTCAGAACAAGGAATTGTCAGATAAGGTCTTGCGGGGCATGGCAGAAGTCCGAGCTGGTCAGGTTCAACTCCAT
GAGATTGAGGGGTAA

Structures

Toxin

• AlphaFold DB: I1ZKJ4