Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3874421..3875067 Replicon chromosome
Accession NZ_CP102687
Organism Klebsiella pneumoniae strain GN4539

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag NV950_RS18880 Protein ID WP_002920560.1
Coordinates 3874421..3874768 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NV950_RS18885 Protein ID WP_002920557.1
Coordinates 3874768..3875067 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV950_RS18870 (NV950_18865) 3870347..3871780 + 1434 WP_002920564.1 glycogen synthase GlgA -
NV950_RS18875 (NV950_18870) 3871798..3874245 + 2448 WP_002920561.1 glycogen phosphorylase -
NV950_RS18880 (NV950_18875) 3874421..3874768 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV950_RS18885 (NV950_18880) 3874768..3875067 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NV950_RS18890 (NV950_18885) 3875130..3876638 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NV950_RS18895 (NV950_18890) 3876843..3877172 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NV950_RS18900 (NV950_18895) 3877223..3878053 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NV950_RS18905 (NV950_18900) 3878103..3878861 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T254011 WP_002920560.1 NZ_CP102687:3874421-3874768 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT254011 WP_002920557.1 NZ_CP102687:3874768-3875067 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References