Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3848238..3848824 Replicon chromosome
Accession NZ_CP102687
Organism Klebsiella pneumoniae strain GN4539

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag NV950_RS18770 Protein ID WP_002920800.1
Coordinates 3848456..3848824 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag NV950_RS18765 Protein ID WP_002920802.1
Coordinates 3848238..3848459 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV950_RS18745 (NV950_18740) 3844395..3845321 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NV950_RS18750 (NV950_18745) 3845318..3846595 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
NV950_RS18755 (NV950_18750) 3846592..3847359 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NV950_RS18760 (NV950_18755) 3847361..3848074 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
NV950_RS18765 (NV950_18760) 3848238..3848459 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NV950_RS18770 (NV950_18765) 3848456..3848824 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NV950_RS18775 (NV950_18770) 3849097..3850413 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
NV950_RS18780 (NV950_18775) 3850520..3851407 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
NV950_RS18785 (NV950_18780) 3851404..3852249 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
NV950_RS18790 (NV950_18785) 3852251..3853321 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3845318..3854058 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T254010 WP_002920800.1 NZ_CP102687:3848456-3848824 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT254010 WP_002920802.1 NZ_CP102687:3848238-3848459 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References