Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3472569..3473110 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag NU949_RS19110 Protein ID WP_000615982.1
Coordinates 3472832..3473110 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NU949_RS19105 Protein ID WP_000729704.1
Coordinates 3472569..3472829 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS19080 (3467605) 3467605..3468744 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
NU949_RS19085 (3468728) 3468728..3470821 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
NU949_RS19090 (3470926) 3470926..3471204 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NU949_RS19095 (3471197) 3471197..3471553 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NU949_RS19100 (3471610) 3471610..3472383 - 774 WP_000543899.1 C40 family peptidase -
NU949_RS19105 (3472569) 3472569..3472829 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NU949_RS19110 (3472832) 3472832..3473110 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NU949_RS19115 (3473266) 3473266..3474006 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NU949_RS19120 (3473977) 3473977..3474744 - 768 WP_000333380.1 class II glutamine amidotransferase -
NU949_RS19125 (3474950) 3474950..3475528 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T253987 WP_000615982.1 NZ_CP102679:3472832-3473110 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT253987 WP_000729704.1 NZ_CP102679:3472569-3472829 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References