Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 289460..290259 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag NU949_RS03540 Protein ID WP_000347266.1
Coordinates 289460..289924 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NU949_RS03545 Protein ID WP_001307405.1
Coordinates 289924..290259 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS03510 (284461) 284461..284895 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NU949_RS03515 (284913) 284913..285791 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
NU949_RS03520 (285781) 285781..286560 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NU949_RS03525 (286571) 286571..287044 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NU949_RS03530 (287067) 287067..288347 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
NU949_RS03535 (288596) 288596..289405 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NU949_RS03540 (289460) 289460..289924 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NU949_RS03545 (289924) 289924..290259 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NU949_RS03550 (290408) 290408..291979 - 1572 WP_001273741.1 galactarate dehydratase -
NU949_RS03555 (292354) 292354..293688 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NU949_RS03560 (293704) 293704..294474 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T253971 WP_000347266.1 NZ_CP102679:c289924-289460 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT253971 WP_001307405.1 NZ_CP102679:c290259-289924 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References