Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3384616..3385415 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag NU950_RS18445 Protein ID WP_000347266.1
Coordinates 3384616..3385080 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NU950_RS18450 Protein ID WP_001307405.1
Coordinates 3385080..3385415 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS18415 (3379617) 3379617..3380051 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NU950_RS18420 (3380069) 3380069..3380947 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
NU950_RS18425 (3380937) 3380937..3381716 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NU950_RS18430 (3381727) 3381727..3382200 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NU950_RS18435 (3382223) 3382223..3383503 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
NU950_RS18440 (3383752) 3383752..3384561 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NU950_RS18445 (3384616) 3384616..3385080 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NU950_RS18450 (3385080) 3385080..3385415 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NU950_RS18455 (3385564) 3385564..3387135 - 1572 WP_001273741.1 galactarate dehydratase -
NU950_RS18460 (3387510) 3387510..3388844 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NU950_RS18465 (3388860) 3388860..3389630 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T253949 WP_000347266.1 NZ_CP102675:c3385080-3384616 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT253949 WP_001307405.1 NZ_CP102675:c3385415-3385080 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References