Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2589738..2590340 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NU950_RS14560 Protein ID WP_000897305.1
Coordinates 2590029..2590340 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NU950_RS14555 Protein ID WP_000356397.1
Coordinates 2589738..2590028 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS14530 (2585683) 2585683..2586585 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NU950_RS14535 (2586582) 2586582..2587217 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NU950_RS14540 (2587214) 2587214..2588143 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NU950_RS14545 (2588473) 2588473..2588715 - 243 WP_001087409.1 protein YiiF -
NU950_RS14550 (2588934) 2588934..2589152 - 219 WP_001295676.1 CopG family transcriptional regulator -
NU950_RS14555 (2589738) 2589738..2590028 - 291 WP_000356397.1 NadS family protein Antitoxin
NU950_RS14560 (2590029) 2590029..2590340 - 312 WP_000897305.1 hypothetical protein Toxin
NU950_RS14565 (2590569) 2590569..2591477 + 909 WP_001162704.1 alpha/beta hydrolase -
NU950_RS14570 (2591541) 2591541..2592482 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NU950_RS14575 (2592527) 2592527..2592964 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NU950_RS14580 (2592961) 2592961..2593833 - 873 WP_000920762.1 virulence factor BrkB family protein -
NU950_RS14585 (2593827) 2593827..2594426 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2588473..2597993 9520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T253947 WP_000897305.1 NZ_CP102675:c2590340-2590029 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT253947 WP_000356397.1 NZ_CP102675:c2590028-2589738 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References