Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1637168..1637709 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag NU950_RS09910 Protein ID WP_000615982.1
Coordinates 1637431..1637709 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NU950_RS09905 Protein ID WP_000729704.1
Coordinates 1637168..1637428 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS09880 (1632204) 1632204..1633343 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
NU950_RS09885 (1633327) 1633327..1635420 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
NU950_RS09890 (1635525) 1635525..1635803 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NU950_RS09895 (1635796) 1635796..1636152 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NU950_RS09900 (1636209) 1636209..1636982 - 774 WP_000543899.1 C40 family peptidase -
NU950_RS09905 (1637168) 1637168..1637428 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NU950_RS09910 (1637431) 1637431..1637709 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NU950_RS09915 (1637865) 1637865..1638605 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NU950_RS09920 (1638576) 1638576..1639343 - 768 WP_000333380.1 class II glutamine amidotransferase -
NU950_RS09925 (1639549) 1639549..1640127 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T253942 WP_000615982.1 NZ_CP102675:1637431-1637709 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT253942 WP_000729704.1 NZ_CP102675:1637168-1637428 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References