Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4764072..4764674 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NUW86_RS23345 Protein ID WP_001159630.1
Coordinates 4764363..4764674 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUW86_RS23340 Protein ID WP_000362050.1
Coordinates 4764072..4764362 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS23325 (4761565) 4761565..4762467 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NUW86_RS23330 (4762464) 4762464..4763099 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NUW86_RS23335 (4763096) 4763096..4764025 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NUW86_RS23340 (4764072) 4764072..4764362 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NUW86_RS23345 (4764363) 4764363..4764674 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NUW86_RS23350 (4764892) 4764892..4765821 + 930 WP_001127703.1 alpha/beta hydrolase -
NUW86_RS23355 (4765907) 4765907..4766218 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NUW86_RS23360 (4766215) 4766215..4766661 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NUW86_RS23365 (4766676) 4766676..4767617 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NUW86_RS23370 (4767662) 4767662..4768099 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NUW86_RS23375 (4768096) 4768096..4768968 - 873 WP_000921427.1 virulence factor BrkB family protein -
NUW86_RS23380 (4768962) 4768962..4769561 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T253924 WP_001159630.1 NZ_CP102669:c4764674-4764363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT253924 WP_000362050.1 NZ_CP102669:c4764362-4764072 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64


Antitoxin

Source ID Structure

References