Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4764072..4764674 | Replicon | chromosome |
Accession | NZ_CP102669 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 |
Toxin (Protein)
Gene name | higB | Uniprot ID | C0Q3J8 |
Locus tag | NUW86_RS23345 | Protein ID | WP_001159630.1 |
Coordinates | 4764363..4764674 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | NUW86_RS23340 | Protein ID | WP_000362050.1 |
Coordinates | 4764072..4764362 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NUW86_RS23325 (4761565) | 4761565..4762467 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
NUW86_RS23330 (4762464) | 4762464..4763099 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
NUW86_RS23335 (4763096) | 4763096..4764025 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
NUW86_RS23340 (4764072) | 4764072..4764362 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | Antitoxin |
NUW86_RS23345 (4764363) | 4764363..4764674 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
NUW86_RS23350 (4764892) | 4764892..4765821 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
NUW86_RS23355 (4765907) | 4765907..4766218 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
NUW86_RS23360 (4766215) | 4766215..4766661 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
NUW86_RS23365 (4766676) | 4766676..4767617 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
NUW86_RS23370 (4767662) | 4767662..4768099 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
NUW86_RS23375 (4768096) | 4768096..4768968 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
NUW86_RS23380 (4768962) | 4768962..4769561 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T253924 WP_001159630.1 NZ_CP102669:c4764674-4764363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10971.59 Da Isoelectric Point: 10.6525
>AT253924 WP_000362050.1 NZ_CP102669:c4764362-4764072 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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