Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2512563..2513085 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NUW86_RS12450 Protein ID WP_000221343.1
Coordinates 2512801..2513085 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NUW86_RS12445 Protein ID WP_000885424.1
Coordinates 2512563..2512811 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS12420 (2507779) 2507779..2509245 + 1467 WP_000987828.1 hypothetical protein -
NUW86_RS12425 (2510053) 2510053..2510767 + 715 Protein_2431 helix-turn-helix domain-containing protein -
NUW86_RS12430 (2510823) 2510823..2511731 - 909 WP_010989018.1 hypothetical protein -
NUW86_RS12435 (2511874) 2511874..2512206 - 333 WP_000253154.1 DUF1493 family protein -
NUW86_RS12440 (2512196) 2512196..2512411 - 216 WP_000206207.1 hypothetical protein -
NUW86_RS12445 (2512563) 2512563..2512811 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NUW86_RS12450 (2512801) 2512801..2513085 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUW86_RS12455 (2513256) 2513256..2513645 + 390 WP_000194089.1 RidA family protein -
NUW86_RS12460 (2513697) 2513697..2514776 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NUW86_RS12465 (2514969) 2514969..2515457 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NUW86_RS12470 (2515502) 2515502..2517010 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2507782..2519867 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T253917 WP_000221343.1 NZ_CP102669:2512801-2513085 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT253917 WP_000885424.1 NZ_CP102669:2512563-2512811 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References