Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 894166..894678 Replicon chromosome
Accession NZ_CP102583
Organism Streptococcus pneumoniae strain D39Mega17545

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag MOP79_RS04650 Protein ID WP_000924721.1
Coordinates 894424..894678 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag MOP79_RS04645 Protein ID WP_000388572.1
Coordinates 894166..894420 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP79_RS04610 889520..889831 + 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -
MOP79_RS04615 889883..890512 + 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
MOP79_RS04620 890512..891105 + 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
MOP79_RS04625 891106..891606 + 501 WP_000844717.1 cysteine hydrolase family protein -
MOP79_RS04630 891619..891972 + 354 WP_001003001.1 ribosome silencing factor -
MOP79_RS04635 892075..892821 + 747 WP_000605157.1 class I SAM-dependent methyltransferase -
MOP79_RS04640 892831..893928 + 1098 WP_000156355.1 nucleotidyltransferase -
MOP79_RS04645 894166..894420 + 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOP79_RS04650 894424..894678 + 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
MOP79_RS04655 894869..896482 + 1614 WP_000404940.1 ribonuclease Y -
MOP79_RS04660 896612..897238 + 627 WP_000775044.1 guanylate kinase -
MOP79_RS04665 897263..897577 + 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T253870 WP_000924721.1 NZ_CP102583:894424-894678 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT253870 WP_000388572.1 NZ_CP102583:894166-894420 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References