Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 813..1443 Replicon plasmid p2
Accession NZ_CP102554
Organism Klebsiella pneumoniae strain KPH3

Toxin (Protein)


Gene name higB Uniprot ID A0A3V9PY09
Locus tag NUG48_RS26670 Protein ID WP_001708474.1
Coordinates 1108..1443 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A704FLZ1
Locus tag NUG48_RS26665 Protein ID WP_001708475.1
Coordinates 813..1103 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG48_RS26660 (NUG48_26665) 100..753 - 654 WP_001708476.1 hypothetical protein -
NUG48_RS26665 (NUG48_26670) 813..1103 - 291 WP_001708475.1 NadS family protein Antitoxin
NUG48_RS26670 (NUG48_26675) 1108..1443 - 336 WP_001708474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG48_RS26675 (NUG48_26680) 1648..2316 - 669 WP_257874035.1 hypothetical protein -
NUG48_RS26680 (NUG48_26685) 2366..2692 - 327 WP_044296048.1 hypothetical protein -
NUG48_RS26685 (NUG48_26690) 3005..3565 - 561 WP_044296046.1 hypothetical protein -
NUG48_RS26690 (NUG48_26695) 3583..3933 - 351 WP_001708471.1 hypothetical protein -
NUG48_RS26695 (NUG48_26700) 3968..4303 - 336 WP_044296044.1 hypothetical protein -
NUG48_RS26700 (NUG48_26705) 4300..4569 - 270 WP_024172976.1 hypothetical protein -
NUG48_RS26705 (NUG48_26710) 4583..4960 - 378 WP_024172975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43141 43141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-104)

Antitoxin

Antitoxin MqsA/HigA-2

(21-94)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12615.30 Da        Isoelectric Point: 5.2407

>T253865 WP_001708474.1 NZ_CP102554:c1443-1108 [Klebsiella pneumoniae]
MEYYEFVETSVFTREMKTLLSDDEYKEFQTFLIENPEAGDLIVGTGGCRKVRWSRQGTGKSSGVRAIYYFYNPAGRLYML
IIYPKSEKDSLTAAEKNQLKAVVAGFKGEEG

Download         Length: 336 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10909.62 Da        Isoelectric Point: 10.0073

>AT253865 WP_001708475.1 NZ_CP102554:c1103-813 [Klebsiella pneumoniae]
MRKELFDDLIASAKEAVEIHQGLREPARVTRFERPDVKAIRAKVHMKQDDFASLIGVSSSLVQSWEQGLRTPAGAALKLL
RVIERKPEFVQELREA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PY09

Antitoxin

Source ID Structure
AlphaFold DB A0A704FLZ1

References