Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3990144..3990784 Replicon chromosome
Accession NZ_CP102546
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NUG47_RS19550 Protein ID WP_016529833.1
Coordinates 3990144..3990491 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUG47_RS19555 Protein ID WP_040181955.1
Coordinates 3990491..3990784 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS19540 (3986070) 3986070..3987503 + 1434 WP_002920564.1 glycogen synthase GlgA -
NUG47_RS19545 (3987521) 3987521..3989968 + 2448 WP_002920561.1 glycogen phosphorylase -
NUG47_RS19550 (3990144) 3990144..3990491 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG47_RS19555 (3990491) 3990491..3990784 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
NUG47_RS19560 (3990854) 3990854..3992362 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
NUG47_RS19565 (3992567) 3992567..3992896 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NUG47_RS19570 (3992947) 3992947..3993777 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
NUG47_RS19575 (3993827) 3993827..3994585 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T253840 WP_016529833.1 NZ_CP102546:3990144-3990491 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT253840 WP_040181955.1 NZ_CP102546:3990491-3990784 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References