253828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2718482..2719004 Replicon chromosome
Accession NZ_CP102542
Organism Lacticaseibacillus rhamnosus strain GR-1

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag NUU07_RS12555 Protein ID WP_005687756.1
Coordinates 2718744..2719004 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag NUU07_RS12550 Protein ID WP_005687754.1
Coordinates 2718482..2718751 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU07_RS12530 (NUU07_12530) 2714068..2714637 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
NUU07_RS12535 (NUU07_12535) 2714650..2715160 - 511 Protein_2429 transcriptional regulator GutM -
NUU07_RS12540 (NUU07_12540) 2715161..2717029 - 1869 WP_014571687.1 HTH domain-containing protein -
NUU07_RS12545 (NUU07_12545) 2717056..2717856 - 801 WP_005690776.1 SDR family oxidoreductase -
NUU07_RS12550 (NUU07_12550) 2718482..2718751 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NUU07_RS12555 (NUU07_12555) 2718744..2719004 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
NUU07_RS12560 (NUU07_12560) 2719215..2719943 - 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
NUU07_RS12565 (NUU07_12565) 2720140..2720961 + 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
NUU07_RS12570 (NUU07_12570) 2721028..2721915 - 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
NUU07_RS12575 (NUU07_12575) 2722100..2722879 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
NUU07_RS12580 (NUU07_12580) 2722947..2723588 - 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T253828 WP_005687756.1 NZ_CP102542:2718744-2719004 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT253828 WP_005687754.1 NZ_CP102542:2718482-2718751 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References