253825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 512910..513395 Replicon chromosome
Accession NZ_CP102542
Organism Lacticaseibacillus rhamnosus strain GR-1

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag NUU07_RS02425 Protein ID WP_005691636.1
Coordinates 512910..513095 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag NUU07_RS02430 Protein ID WP_014571130.1
Coordinates 513123..513395 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU07_RS02405 (NUU07_02405) 507917..508606 + 690 WP_005691628.1 rhomboid family intramembrane serine protease -
NUU07_RS02410 (NUU07_02410) 509098..509706 - 609 WP_005691630.1 hypothetical protein -
NUU07_RS02415 (NUU07_02415) 510153..511028 + 876 WP_024305787.1 XRE family transcriptional regulator -
NUU07_RS02420 (NUU07_02420) 511271..512686 - 1416 WP_005691634.1 exonuclease domain-containing protein -
NUU07_RS02425 (NUU07_02425) 512910..513095 - 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NUU07_RS02430 (NUU07_02430) 513123..513395 - 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU07_RS02435 (NUU07_02435) 513957..514205 + 249 WP_005691639.1 hypothetical protein -
NUU07_RS02440 (NUU07_02440) 514448..514741 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
NUU07_RS02445 (NUU07_02445) 514823..515986 + 1164 WP_005691640.1 MFS transporter -
NUU07_RS02450 (NUU07_02450) 516140..516715 + 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
NUU07_RS02455 (NUU07_02455) 516837..517055 + 219 WP_005691646.1 hypothetical protein -
NUU07_RS02460 (NUU07_02460) 517184..518065 - 882 WP_005684263.1 class II fructose-1,6-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T253825 WP_005691636.1 NZ_CP102542:c513095-512910 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT253825 WP_014571130.1 NZ_CP102542:c513395-513123 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References