Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1379513..1380077 Replicon chromosome
Accession NZ_CP102530
Organism Lacticaseibacillus paracasei subsp. paracasei strain 01

Toxin (Protein)


Gene name yafQ Uniprot ID A0A6G9EML4
Locus tag NUU02_RS07050 Protein ID WP_014951859.1
Coordinates 1379775..1380077 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag NUU02_RS07045 Protein ID WP_003570051.1
Coordinates 1379513..1379782 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU02_RS07015 (NUU02_07015) 1374517..1375404 - 888 WP_012491506.1 ABC transporter ATP-binding protein -
NUU02_RS07020 (NUU02_07020) 1375602..1376828 - 1227 WP_012491507.1 hypothetical protein -
NUU02_RS07025 (NUU02_07025) 1377026..1377430 + 405 WP_012491508.1 MerR family transcriptional regulator -
NUU02_RS07030 (NUU02_07030) 1377423..1377749 + 327 WP_012491509.1 YrdB family protein -
NUU02_RS07035 (NUU02_07035) 1377812..1378441 + 630 WP_012491510.1 DUF2399 domain-containing protein -
NUU02_RS07040 (NUU02_07040) 1378486..1379139 + 654 WP_012491511.1 N-acetyltransferase -
NUU02_RS07045 (NUU02_07045) 1379513..1379782 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU02_RS07050 (NUU02_07050) 1379775..1380077 + 303 WP_014951859.1 type II toxin-antitoxin system YafQ family toxin Toxin
NUU02_RS07055 (NUU02_07055) 1380416..1380559 + 144 WP_003574774.1 hypothetical protein -
NUU02_RS07060 (NUU02_07060) 1380677..1381369 + 693 WP_012491513.1 hypothetical protein -
NUU02_RS07065 (NUU02_07065) 1381605..1383782 + 2178 WP_012491514.1 Tex family protein -
NUU02_RS07070 (NUU02_07070) 1383847..1384776 - 930 WP_003599410.1 IS30-like element ISLpl1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1383847..1384776 929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.27 Da        Isoelectric Point: 10.2818

>T253811 WP_014951859.1 NZ_CP102530:1379775-1380077 [Lacticaseibacillus paracasei subsp. paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT253811 WP_003570051.1 NZ_CP102530:1379513-1379782 [Lacticaseibacillus paracasei subsp. paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9EML4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References