253793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4835189..4835943 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NUG39_RS23240 Protein ID WP_115601211.1
Coordinates 4835189..4835500 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUG39_RS23245 Protein ID WP_048214030.1
Coordinates 4835497..4835943 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS23210 (4830856) 4830856..4831758 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
NUG39_RS23215 (4831755) 4831755..4832390 + 636 WP_043018888.1 formate dehydrogenase cytochrome b556 subunit -
NUG39_RS23220 (4832387) 4832387..4833316 + 930 WP_257748514.1 formate dehydrogenase accessory protein FdhE -
NUG39_RS23225 (4833353) 4833353..4833727 - 375 WP_101741972.1 type II toxin-antitoxin system VapC family toxin -
NUG39_RS23230 (4833727) 4833727..4833969 - 243 WP_005121822.1 CopG family transcriptional regulator -
NUG39_RS23235 (4834174) 4834174..4835103 + 930 WP_257748517.1 alpha/beta hydrolase -
NUG39_RS23240 (4835189) 4835189..4835500 + 312 WP_115601211.1 type II toxin-antitoxin system HigB family toxin Toxin
NUG39_RS23245 (4835497) 4835497..4835943 + 447 WP_048214030.1 helix-turn-helix domain-containing protein Antitoxin
NUG39_RS23250 (4835955) 4835955..4836896 - 942 WP_048214031.1 fatty acid biosynthesis protein FabY -
NUG39_RS23255 (4836941) 4836941..4837378 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
NUG39_RS23260 (4837375) 4837375..4838247 - 873 WP_116361127.1 virulence factor BrkB family protein -
NUG39_RS23265 (4838241) 4838241..4838840 - 600 WP_101741977.1 glucose-1-phosphatase -
NUG39_RS23270 (4838946) 4838946..4839749 - 804 WP_003847907.1 DeoR/GlpR family DNA-binding transcription regulator -
NUG39_RS23275 (4839783) 4839783..4840679 - 897 WP_257748521.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12452.44 Da        Isoelectric Point: 9.5344

>T253793 WP_115601211.1 NZ_CP102500:4835189-4835500 [Citrobacter youngae]
VHVISRKPFNEGMLMYPNHGLALSELLNVLEKKTFHHPEEMKQYIPSLDNFKYRNKWWVIDVSGNNLRLIAYIDFRLHKV
FVKHIVLHAEYDKLTEYYRGHKE

Download         Length: 312 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16695.12 Da        Isoelectric Point: 7.0634

>AT253793 WP_048214030.1 NZ_CP102500:4835497-4835943 [Citrobacter youngae]
MRSHRHMDAASAKKIVDTFSCAVKTIPLLGEERNETEYRRALALVEFLVDHDDLENPLFELLSARISEYEKHAPEFRALN
QHLKQIPPGVSVLRTLMDQYGLKATDLANELGSKSNVSNILNGRRALTVSHIKALAERFKLPADAFIE

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References