253790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4584905..4585575 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name higB Uniprot ID A0A6N6JXY6
Locus tag NUG39_RS22090 Protein ID WP_046671374.1
Coordinates 4585273..4585575 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUG39_RS22085 Protein ID WP_048213890.1
Coordinates 4584905..4585246 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS22055 (4580526) 4580526..4581284 + 759 WP_048213884.1 phosphonate C-P lyase system protein PhnK -
NUG39_RS22060 (4581294) 4581294..4581974 + 681 WP_115644030.1 phosphonate C-P lyase system protein PhnL -
NUG39_RS22065 (4581971) 4581971..4583107 + 1137 WP_257748446.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
NUG39_RS22070 (4583110) 4583110..4583664 + 555 WP_101742857.1 ribose 1,5-bisphosphokinase -
NUG39_RS22075 (4583651) 4583651..4584085 + 435 WP_116360963.1 aminoalkylphosphonate N-acetyltransferase -
NUG39_RS22080 (4584094) 4584094..4584852 + 759 WP_257748447.1 phosphonate metabolism protein PhnP -
NUG39_RS22085 (4584905) 4584905..4585246 - 342 WP_048213890.1 HigA family addiction module antitoxin Antitoxin
NUG39_RS22090 (4585273) 4585273..4585575 - 303 WP_046671374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG39_RS22095 (4585731) 4585731..4586060 - 330 WP_172743423.1 DDRRRQL repeat protein YjdP -
NUG39_RS22100 (4586130) 4586130..4588394 - 2265 WP_257748448.1 hybrid sensor histidine kinase/response regulator -
NUG39_RS22105 (4588509) 4588509..4590032 + 1524 WP_257748449.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11819.43 Da        Isoelectric Point: 9.9581

>T253790 WP_046671374.1 NZ_CP102500:c4585575-4585273 [Citrobacter youngae]
MSKSLNIRSFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWVNGKAEDVYLDPHIY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13089.90 Da        Isoelectric Point: 6.4763

>AT253790 WP_048213890.1 NZ_CP102500:c4585246-4584905 [Citrobacter youngae]
MKQATRKPTTVGDILQYEYLEPLELKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNSESKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JXY6

Antitoxin

Source ID Structure

References