253785

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3015730..3016390 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NUG39_RS14795 Protein ID WP_257748004.1
Coordinates 3016037..3016390 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUG39_RS14790 Protein ID WP_257748003.1
Coordinates 3015730..3016032 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS14780 (3012491) 3012491..3013753 + 1263 WP_257748001.1 integrase arm-type DNA-binding domain-containing protein -
NUG39_RS14785 (3014334) 3014334..3015221 - 888 WP_257748002.1 integrase domain-containing protein -
NUG39_RS14790 (3015730) 3015730..3016032 - 303 WP_257748003.1 helix-turn-helix domain-containing protein Antitoxin
NUG39_RS14795 (3016037) 3016037..3016390 - 354 WP_257748004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG39_RS14800 (3016887) 3016887..3017093 - 207 WP_257748005.1 helix-turn-helix transcriptional regulator -
NUG39_RS14805 (3017090) 3017090..3017557 - 468 WP_257748006.1 hypothetical protein -
NUG39_RS14810 (3017862) 3017862..3018863 - 1002 WP_257748007.1 DUF4917 family protein -
NUG39_RS14815 (3019141) 3019141..3020376 + 1236 WP_257748008.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13425.38 Da        Isoelectric Point: 7.5863

>T253785 WP_257748004.1 NZ_CP102500:c3016390-3016037 [Citrobacter youngae]
MWTIKTTDRFDDWFSALCATDRACVLASLLVLREKGPGLPRPYADTIKGSCYNNMKELRVQSRGDPIRIFFAFDPYRTGI
LLCAGNKVGNEKRFYNQMVAVADREFAEYLNTLDDKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11129.91 Da        Isoelectric Point: 6.4717

>AT253785 WP_257748003.1 NZ_CP102500:c3016032-3015730 [Citrobacter youngae]
MGRTLEQLLADEKRDIVADAQAMAADILLNIHLAELREKVQKTQVEMAQTLGIRQPTVASMEKPGRDLKLSTLKRYVEAT
GGKLRLDIELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References