253769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3898752..3899349 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag LCN95_RS18980 Protein ID WP_004142563.1
Coordinates 3899032..3899349 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag LCN95_RS18975 Protein ID WP_004142561.1
Coordinates 3898752..3899039 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS18945 (LCN95_18950) 3894832..3895080 + 249 WP_002893037.1 DUF1158 domain-containing protein -
LCN95_RS18950 (LCN95_18955) 3895098..3895439 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LCN95_RS18955 (LCN95_18960) 3895470..3896585 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
LCN95_RS18960 (LCN95_18965) 3896765..3897346 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
LCN95_RS18965 (LCN95_18970) 3897346..3897714 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
LCN95_RS18970 (LCN95_18975) 3897834..3898487 + 654 WP_019704893.1 oxygen-insensitive NAD(P)H nitroreductase -
LCN95_RS18975 (LCN95_18980) 3898752..3899039 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
LCN95_RS18980 (LCN95_18985) 3899032..3899349 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCN95_RS18985 (LCN95_18990) 3899534..3900577 - 1044 WP_019704892.1 DUF2157 domain-containing protein -
LCN95_RS18990 (LCN95_18995) 3901247..3902113 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
LCN95_RS18995 (LCN95_19000) 3902222..3903649 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T253769 WP_004142563.1 NZ_CP102490:c3899349-3899032 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT253769 WP_004142561.1 NZ_CP102490:c3899039-3898752 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References