Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4529060..4529753 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NUI00_RS22055 Protein ID WP_000415584.1
Coordinates 4529060..4529356 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NUI00_RS22060 Protein ID WP_000650107.1
Coordinates 4529358..4529753 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS22020 (4524139) 4524139..4524453 - 315 WP_000958598.1 putative quinol monooxygenase -
NUI00_RS22025 (4524484) 4524484..4525065 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NUI00_RS22030 (4525393) 4525393..4525725 + 333 WP_000917684.1 DUF2645 family protein -
NUI00_RS22035 (4525771) 4525771..4527120 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NUI00_RS22040 (4527117) 4527117..4527776 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NUI00_RS22045 (4527928) 4527928..4528320 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NUI00_RS22050 (4528373) 4528373..4528855 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NUI00_RS22055 (4529060) 4529060..4529356 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NUI00_RS22060 (4529358) 4529358..4529753 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NUI00_RS22065 (4529886) 4529886..4531493 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NUI00_RS22070 (4531631) 4531631..4533889 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T253756 WP_000415584.1 NZ_CP102488:4529060-4529356 [Escherichia coli O15:H18]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT253756 WP_000650107.1 NZ_CP102488:4529358-4529753 [Escherichia coli O15:H18]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References