253754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4423307..4424106 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag NUI00_RS21530 Protein ID WP_000347269.1
Coordinates 4423307..4423771 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag NUI00_RS21535 Protein ID WP_001309780.1
Coordinates 4423771..4424106 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS21500 (4418308) 4418308..4418742 - 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NUI00_RS21505 (4418760) 4418760..4419638 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NUI00_RS21510 (4419628) 4419628..4420407 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NUI00_RS21515 (4420418) 4420418..4420891 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NUI00_RS21520 (4420914) 4420914..4422194 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
NUI00_RS21525 (4422443) 4422443..4423252 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
NUI00_RS21530 (4423307) 4423307..4423771 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NUI00_RS21535 (4423771) 4423771..4424106 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NUI00_RS21540 (4424255) 4424255..4425826 - 1572 WP_001273738.1 galactarate dehydratase -
NUI00_RS21545 (4426201) 4426201..4427535 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NUI00_RS21550 (4427551) 4427551..4428321 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T253754 WP_000347269.1 NZ_CP102488:c4423771-4423307 [Escherichia coli O15:H18]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT253754 WP_001309780.1 NZ_CP102488:c4424106-4423771 [Escherichia coli O15:H18]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References