Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2432417..2433078 Replicon chromosome
Accession NZ_CP102487
Organism Glutamicibacter halophytocola strain S2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag NUH22_RS11300 Protein ID WP_236995176.1
Coordinates 2432728..2433078 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag NUH22_RS11295 Protein ID WP_236995175.1
Coordinates 2432417..2432731 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUH22_RS11275 (NUH22_11275) 2427834..2429261 + 1428 WP_194943653.1 MFS transporter -
NUH22_RS11280 (NUH22_11280) 2429278..2430450 + 1173 WP_257745334.1 amidohydrolase -
NUH22_RS11285 (NUH22_11285) 2431358..2431894 - 537 WP_146275611.1 isochorismatase family protein -
NUH22_RS11290 (NUH22_11290) 2431894..2432196 - 303 WP_060702101.1 HigA family addiction module antitoxin -
NUH22_RS11295 (NUH22_11295) 2432417..2432731 - 315 WP_236995175.1 helix-turn-helix transcriptional regulator Antitoxin
NUH22_RS11300 (NUH22_11300) 2432728..2433078 - 351 WP_236995176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUH22_RS11305 (NUH22_11305) 2433231..2434316 - 1086 WP_146275617.1 redox-regulated ATPase YchF -
NUH22_RS11310 (NUH22_11310) 2434378..2435475 - 1098 WP_060702139.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
NUH22_RS11315 (NUH22_11315) 2435576..2436769 - 1194 WP_257745335.1 SH3 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-96)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13113.89 Da        Isoelectric Point: 4.4991

>T253735 WP_236995176.1 NZ_CP102487:c2433078-2432728 [Glutamicibacter halophytocola]
VDIELIELIEVWLAELDVDSREQVVAAIELLEDSGPQLGRPIVDTVKASRHKNIKELRPGSSGKSELRILFAFDPERAAI
MLIAGDKAGDWQGWYEKNLPHADRLFDEHLDKIRGE

Download         Length: 351 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11789.48 Da        Isoelectric Point: 8.5142

>AT253735 WP_236995175.1 NZ_CP102487:c2432731-2432417 [Glutamicibacter halophytocola]
VSALAKSLKDFLAQNPVDRDRVEKHKQRMLAEVRAYRLRELREQAGLTQAELAERIGVGQRQVSKIEHGDLENAKIGTIR
NYLEAVGGELSLEYLMGDQRMQIA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References