Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1209216..1209796 Replicon chromosome
Accession NZ_CP102480
Organism Nisaea acidiphila strain MEBiC11861

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NUH88_RS05605 Protein ID WP_257770491.1
Coordinates 1209216..1209497 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUH88_RS05610 Protein ID WP_257770493.1
Coordinates 1209497..1209796 (+) Length 100 a.a.

Genomic Context

NUH88_RS05590NUH88_RS05595NUH88_RS05600NUH88_RS05605NUH88_RS05610NUH88_RS05615NUH88_RS05620NUH88_RS05625NUH88_RS05630
Location: 1204869..1206773 (1905 bp)
Type: Others
Protein ID: WP_257770485.1
Location: 1207013..1207822 (810 bp)
Type: Others
Protein ID: WP_257770487.1
Location: 1207978..1208649 (672 bp)
Type: Others
Protein ID: WP_257770489.1
Location: 1209216..1209497 (282 bp)
Type: Toxin
Protein ID: WP_257770491.1
Location: 1209497..1209796 (300 bp)
Type: Antitoxin
Protein ID: WP_257770493.1
Location: 1210010..1210282 (273 bp)
Type: Others
Protein ID: WP_257770495.1
Location: 1210543..1211529 (987 bp)
Type: Others
Protein ID: WP_257770497.1
Location: 1211643..1212266 (624 bp)
Type: Others
Protein ID: WP_257770499.1
Location: 1212557..1214383 (1827 bp)
Type: Others
Protein ID: WP_257770501.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NUH88_RS05590 (NUH88_05590)1204869..1206773+1905WP_257770485.1molecular chaperone HtpG-
NUH88_RS05595 (NUH88_05595)1207013..1207822+810WP_257770487.1hypothetical protein-
NUH88_RS05600 (NUH88_05600)1207978..1208649+672WP_257770489.1hypothetical protein-
NUH88_RS05605 (NUH88_05605)1209216..1209497+282WP_257770491.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NUH88_RS05610 (NUH88_05610)1209497..1209796+300WP_257770493.1HigA family addiction module antitoxinAntitoxin
NUH88_RS05615 (NUH88_05615)1210010..1210282+273WP_257770495.1hypothetical protein-
NUH88_RS05620 (NUH88_05620)1210543..1211529+987WP_257770497.1phosphoribosylaminoimidazolesuccinocarboxamide synthase-
NUH88_RS05625 (NUH88_05625)1211643..1212266-624WP_257770499.1DUF2799 domain-containing protein-
NUH88_RS05630 (NUH88_05630)1212557..1214383-1827WP_257770501.1NAD(P)/FAD-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10311.71 Da        Isoelectric Point: 10.6229

>T253720 WP_257770491.1 NZ_CP102480:1209216-1209497 [Nisaea acidiphila]
MIKSISHKGLRQFAATGKGGKLPVQGAAQNRLVQMLQTLNAASQPEDMNLPGFHFHALTGDRKGTYSVRVTANWRLTFEW
NSGATNVKLEDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10857.74 Da        Isoelectric Point: 8.0512

>AT253720 WP_257770493.1 NZ_CP102480:1209497-1209796 [Nisaea acidiphila]
MLKGLPPMHPGALLRDQILPELGVSKTRLAENLKISRQTLHDILSEKAPVTAQMALRLGKLCGNGPTIWVNLQSQWDIAQ
AEKDLADIIEQIPTLQKAG

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References