Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1209216..1209796 Replicon chromosome
Accession NZ_CP102480
Organism Nisaea acidiphila strain MEBiC11861

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NUH88_RS05605 Protein ID WP_257770491.1
Coordinates 1209216..1209497 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NUH88_RS05610 Protein ID WP_257770493.1
Coordinates 1209497..1209796 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUH88_RS05590 (NUH88_05590) 1204869..1206773 + 1905 WP_257770485.1 molecular chaperone HtpG -
NUH88_RS05595 (NUH88_05595) 1207013..1207822 + 810 WP_257770487.1 hypothetical protein -
NUH88_RS05600 (NUH88_05600) 1207978..1208649 + 672 WP_257770489.1 hypothetical protein -
NUH88_RS05605 (NUH88_05605) 1209216..1209497 + 282 WP_257770491.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUH88_RS05610 (NUH88_05610) 1209497..1209796 + 300 WP_257770493.1 HigA family addiction module antitoxin Antitoxin
NUH88_RS05615 (NUH88_05615) 1210010..1210282 + 273 WP_257770495.1 hypothetical protein -
NUH88_RS05620 (NUH88_05620) 1210543..1211529 + 987 WP_257770497.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NUH88_RS05625 (NUH88_05625) 1211643..1212266 - 624 WP_257770499.1 DUF2799 domain-containing protein -
NUH88_RS05630 (NUH88_05630) 1212557..1214383 - 1827 WP_257770501.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10311.71 Da        Isoelectric Point: 10.6229

>T253720 WP_257770491.1 NZ_CP102480:1209216-1209497 [Nisaea acidiphila]
MIKSISHKGLRQFAATGKGGKLPVQGAAQNRLVQMLQTLNAASQPEDMNLPGFHFHALTGDRKGTYSVRVTANWRLTFEW
NSGATNVKLEDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10857.74 Da        Isoelectric Point: 8.0512

>AT253720 WP_257770493.1 NZ_CP102480:1209497-1209796 [Nisaea acidiphila]
MLKGLPPMHPGALLRDQILPELGVSKTRLAENLKISRQTLHDILSEKAPVTAQMALRLGKLCGNGPTIWVNLQSQWDIAQ
AEKDLADIIEQIPTLQKAG

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References