253672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 799565..800160 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NR803_RS03820 Protein ID WP_003113526.1
Coordinates 799565..799843 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NR803_RS03825 Protein ID WP_003099268.1
Coordinates 799855..800160 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS03800 (NR803_03800) 794991..796229 + 1239 WP_003113524.1 dipeptidase -
NR803_RS03805 (NR803_03805) 796291..796938 + 648 WP_003095021.1 carbonate dehydratase -
NR803_RS03810 (NR803_03810) 797008..799236 - 2229 WP_003099265.1 TonB-dependent receptor -
NR803_RS03815 (NR803_03815) 799384..799512 + 129 Protein_755 integrase -
NR803_RS03820 (NR803_03820) 799565..799843 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NR803_RS03825 (NR803_03825) 799855..800160 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
NR803_RS03830 (NR803_03830) 800778..801953 + 1176 WP_071557852.1 reverse transcriptase family protein -
NR803_RS03835 (NR803_03835) 801940..802641 + 702 WP_152959654.1 retron Ec48 family effector membrane protein -
NR803_RS03840 (NR803_03840) 802644..802979 - 336 WP_058175552.1 hypothetical protein -
NR803_RS03845 (NR803_03845) 803426..803698 + 273 WP_058175553.1 hypothetical protein -
NR803_RS03850 (NR803_03850) 803874..804164 + 291 WP_152959653.1 DUF5447 family protein -
NR803_RS03855 (NR803_03855) 804680..805114 + 435 WP_009875803.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T253672 WP_003113526.1 NZ_CP102441:799565-799843 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT253672 WP_003099268.1 NZ_CP102441:799855-800160 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References