253603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 746222..746997 Replicon chromosome
Accession NZ_CP102390
Organism Klebsiella pneumoniae strain K64

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NRF21_RS03725 Protein ID WP_004150910.1
Coordinates 746512..746997 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NRF21_RS03720 Protein ID WP_004150912.1
Coordinates 746222..746515 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS03700 (NRF21_03700) 741430..742032 - 603 WP_062954968.1 short chain dehydrogenase -
NRF21_RS03705 (NRF21_03705) 742130..743041 + 912 WP_004188550.1 LysR family transcriptional regulator -
NRF21_RS03710 (NRF21_03710) 743042..744190 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NRF21_RS03715 (NRF21_03715) 744201..745577 - 1377 WP_004217775.1 cystathionine beta-synthase -
NRF21_RS03720 (NRF21_03720) 746222..746515 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NRF21_RS03725 (NRF21_03725) 746512..746997 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NRF21_RS03730 (NRF21_03730) 747701..748294 + 594 WP_004188553.1 hypothetical protein -
NRF21_RS03735 (NRF21_03735) 748391..748607 + 217 Protein_734 transposase -
NRF21_RS03740 (NRF21_03740) 749213..750085 + 873 WP_004188557.1 ParA family protein -
NRF21_RS03745 (NRF21_03745) 750085..750468 + 384 WP_004150906.1 hypothetical protein -
NRF21_RS03750 (NRF21_03750) 750461..751828 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 748391..748543 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T253603 WP_004150910.1 NZ_CP102390:746512-746997 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT253603 WP_004150912.1 NZ_CP102390:746222-746515 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References