253586

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3038954..3039647 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NR349_RS14765 Protein ID WP_000415584.1
Coordinates 3039351..3039647 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NR349_RS14760 Protein ID WP_000650107.1
Coordinates 3038954..3039349 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS14750 (3034818) 3034818..3037076 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
NR349_RS14755 (3037214) 3037214..3038821 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NR349_RS14760 (3038954) 3038954..3039349 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NR349_RS14765 (3039351) 3039351..3039647 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NR349_RS14770 (3039852) 3039852..3040334 - 483 WP_000183505.1 GyrI-like domain-containing protein -
NR349_RS14775 (3040387) 3040387..3040779 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NR349_RS14780 (3040931) 3040931..3041590 + 660 WP_262513199.1 quorum sensing response regulator transcription factor QseB -
NR349_RS14785 (3041587) 3041587..3042936 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NR349_RS14790 (3042982) 3042982..3043314 - 333 WP_000917684.1 DUF2645 family protein -
NR349_RS14795 (3043633) 3043633..3044214 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NR349_RS14800 (3044245) 3044245..3044559 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T253586 WP_000415584.1 NZ_CP102380:c3039647-3039351 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT253586 WP_000650107.1 NZ_CP102380:c3039349-3038954 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References