253581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1967559..1968061 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NR349_RS09750 Protein ID WP_000767829.1
Coordinates 1967559..1967813 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NR349_RS09755 Protein ID WP_001259255.1
Coordinates 1967810..1968061 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS09720 (1962574) 1962574..1962801 - 228 WP_000234896.1 sulfurtransferase TusA -
NR349_RS09725 (1962815) 1962815..1963873 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
NR349_RS09730 (1964052) 1964052..1965410 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NR349_RS09735 (1965400) 1965400..1965462 - 63 WP_010723108.1 membrane protein YoeI -
NR349_RS09740 (1965677) 1965677..1966606 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NR349_RS09745 (1966652) 1966652..1967476 - 825 WP_000754737.1 SDR family oxidoreductase -
NR349_RS09750 (1967559) 1967559..1967813 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NR349_RS09755 (1967810) 1967810..1968061 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NR349_RS09760 (1968344) 1968344..1968394 + 51 WP_001364200.1 his operon leader peptide -
NR349_RS09765 (1968540) 1968540..1969439 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NR349_RS09770 (1969445) 1969445..1970749 + 1305 WP_000009594.1 histidinol dehydrogenase -
NR349_RS09775 (1970746) 1970746..1971816 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
NR349_RS09780 (1971816) 1971816..1972883 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T253581 WP_000767829.1 NZ_CP102380:c1967813-1967559 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT253581 WP_001259255.1 NZ_CP102380:c1968061-1967810 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References