Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-symR/Ldr(toxin)
Location 1143876..1144098 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag NR350_RS05540 Protein ID WP_000170955.1
Coordinates 1143876..1143983 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1144031..1144098 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS05510 (1139732) 1139732..1140565 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
NR350_RS05515 (1140562) 1140562..1140954 + 393 WP_000200374.1 invasion regulator SirB2 -
NR350_RS05520 (1140958) 1140958..1141767 + 810 WP_001257044.1 invasion regulator SirB1 -
NR350_RS05525 (1141803) 1141803..1142657 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
NR350_RS05530 (1142806) 1142806..1142913 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1142961) 1142961..1143027 + 67 NuclAT_33 - -
- (1142961) 1142961..1143027 + 67 NuclAT_33 - -
- (1142961) 1142961..1143027 + 67 NuclAT_33 - -
- (1142961) 1142961..1143027 + 67 NuclAT_33 - -
- (1142961) 1142961..1143027 + 67 NuclAT_35 - -
- (1142961) 1142961..1143027 + 67 NuclAT_35 - -
- (1142961) 1142961..1143027 + 67 NuclAT_35 - -
- (1142961) 1142961..1143027 + 67 NuclAT_35 - -
- (1142961) 1142961..1143027 + 67 NuclAT_37 - -
- (1142961) 1142961..1143027 + 67 NuclAT_37 - -
- (1142961) 1142961..1143027 + 67 NuclAT_37 - -
- (1142961) 1142961..1143027 + 67 NuclAT_37 - -
- (1142961) 1142961..1143027 + 67 NuclAT_39 - -
- (1142961) 1142961..1143027 + 67 NuclAT_39 - -
- (1142961) 1142961..1143027 + 67 NuclAT_39 - -
- (1142961) 1142961..1143027 + 67 NuclAT_39 - -
- (1142961) 1142961..1143027 + 67 NuclAT_41 - -
- (1142961) 1142961..1143027 + 67 NuclAT_41 - -
- (1142961) 1142961..1143027 + 67 NuclAT_41 - -
- (1142961) 1142961..1143027 + 67 NuclAT_41 - -
- (1142961) 1142961..1143027 + 67 NuclAT_43 - -
- (1142961) 1142961..1143027 + 67 NuclAT_43 - -
- (1142961) 1142961..1143027 + 67 NuclAT_43 - -
- (1142961) 1142961..1143027 + 67 NuclAT_43 - -
- (1142963) 1142963..1143028 + 66 NuclAT_17 - -
- (1142963) 1142963..1143028 + 66 NuclAT_17 - -
- (1142963) 1142963..1143028 + 66 NuclAT_17 - -
- (1142963) 1142963..1143028 + 66 NuclAT_17 - -
- (1142963) 1142963..1143028 + 66 NuclAT_20 - -
- (1142963) 1142963..1143028 + 66 NuclAT_20 - -
- (1142963) 1142963..1143028 + 66 NuclAT_20 - -
- (1142963) 1142963..1143028 + 66 NuclAT_20 - -
- (1142963) 1142963..1143028 + 66 NuclAT_23 - -
- (1142963) 1142963..1143028 + 66 NuclAT_23 - -
- (1142963) 1142963..1143028 + 66 NuclAT_23 - -
- (1142963) 1142963..1143028 + 66 NuclAT_23 - -
- (1142963) 1142963..1143028 + 66 NuclAT_26 - -
- (1142963) 1142963..1143028 + 66 NuclAT_26 - -
- (1142963) 1142963..1143028 + 66 NuclAT_26 - -
- (1142963) 1142963..1143028 + 66 NuclAT_26 - -
- (1142963) 1142963..1143028 + 66 NuclAT_29 - -
- (1142963) 1142963..1143028 + 66 NuclAT_29 - -
- (1142963) 1142963..1143028 + 66 NuclAT_29 - -
- (1142963) 1142963..1143028 + 66 NuclAT_29 - -
- (1142963) 1142963..1143028 + 66 NuclAT_32 - -
- (1142963) 1142963..1143028 + 66 NuclAT_32 - -
- (1142963) 1142963..1143028 + 66 NuclAT_32 - -
- (1142963) 1142963..1143028 + 66 NuclAT_32 - -
NR350_RS05535 (1143341) 1143341..1143448 - 108 WP_000170963.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1143497) 1143497..1143562 + 66 NuclAT_34 - -
- (1143497) 1143497..1143562 + 66 NuclAT_34 - -
- (1143497) 1143497..1143562 + 66 NuclAT_34 - -
- (1143497) 1143497..1143562 + 66 NuclAT_34 - -
- (1143497) 1143497..1143562 + 66 NuclAT_36 - -
- (1143497) 1143497..1143562 + 66 NuclAT_36 - -
- (1143497) 1143497..1143562 + 66 NuclAT_36 - -
- (1143497) 1143497..1143562 + 66 NuclAT_36 - -
- (1143497) 1143497..1143562 + 66 NuclAT_38 - -
- (1143497) 1143497..1143562 + 66 NuclAT_38 - -
- (1143497) 1143497..1143562 + 66 NuclAT_38 - -
- (1143497) 1143497..1143562 + 66 NuclAT_38 - -
- (1143497) 1143497..1143562 + 66 NuclAT_40 - -
- (1143497) 1143497..1143562 + 66 NuclAT_40 - -
- (1143497) 1143497..1143562 + 66 NuclAT_40 - -
- (1143497) 1143497..1143562 + 66 NuclAT_40 - -
- (1143497) 1143497..1143562 + 66 NuclAT_42 - -
- (1143497) 1143497..1143562 + 66 NuclAT_42 - -
- (1143497) 1143497..1143562 + 66 NuclAT_42 - -
- (1143497) 1143497..1143562 + 66 NuclAT_42 - -
- (1143497) 1143497..1143562 + 66 NuclAT_44 - -
- (1143497) 1143497..1143562 + 66 NuclAT_44 - -
- (1143497) 1143497..1143562 + 66 NuclAT_44 - -
- (1143497) 1143497..1143562 + 66 NuclAT_44 - -
- (1143496) 1143496..1143563 + 68 NuclAT_16 - -
- (1143496) 1143496..1143563 + 68 NuclAT_16 - -
- (1143496) 1143496..1143563 + 68 NuclAT_16 - -
- (1143496) 1143496..1143563 + 68 NuclAT_16 - -
- (1143496) 1143496..1143563 + 68 NuclAT_19 - -
- (1143496) 1143496..1143563 + 68 NuclAT_19 - -
- (1143496) 1143496..1143563 + 68 NuclAT_19 - -
- (1143496) 1143496..1143563 + 68 NuclAT_19 - -
- (1143496) 1143496..1143563 + 68 NuclAT_22 - -
- (1143496) 1143496..1143563 + 68 NuclAT_22 - -
- (1143496) 1143496..1143563 + 68 NuclAT_22 - -
- (1143496) 1143496..1143563 + 68 NuclAT_22 - -
- (1143496) 1143496..1143563 + 68 NuclAT_25 - -
- (1143496) 1143496..1143563 + 68 NuclAT_25 - -
- (1143496) 1143496..1143563 + 68 NuclAT_25 - -
- (1143496) 1143496..1143563 + 68 NuclAT_25 - -
- (1143496) 1143496..1143563 + 68 NuclAT_28 - -
- (1143496) 1143496..1143563 + 68 NuclAT_28 - -
- (1143496) 1143496..1143563 + 68 NuclAT_28 - -
- (1143496) 1143496..1143563 + 68 NuclAT_28 - -
- (1143496) 1143496..1143563 + 68 NuclAT_31 - -
- (1143496) 1143496..1143563 + 68 NuclAT_31 - -
- (1143496) 1143496..1143563 + 68 NuclAT_31 - -
- (1143496) 1143496..1143563 + 68 NuclAT_31 - -
NR350_RS05540 (1143876) 1143876..1143983 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (1144031) 1144031..1144098 + 68 NuclAT_15 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_15 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_15 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_15 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_18 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_18 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_18 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_18 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_21 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_21 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_21 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_21 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_24 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_24 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_24 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_24 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_27 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_27 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_27 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_27 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_30 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_30 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_30 - Antitoxin
- (1144031) 1144031..1144098 + 68 NuclAT_30 - Antitoxin
NR350_RS05545 (1144387) 1144387..1145487 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
NR350_RS05550 (1145757) 1145757..1145987 + 231 WP_001146444.1 putative cation transport regulator ChaB -
NR350_RS05555 (1146145) 1146145..1146840 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
NR350_RS05560 (1146884) 1146884..1147237 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
NR350_RS05565 (1147422) 1147422..1148816 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T253533 WP_000170955.1 NZ_CP102379:c1143983-1143876 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

Antitoxin


Download         Length: 68 bp

>AT253533 NZ_CP102379:1144031-1144098 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References