Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3178487..3179180 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NR351_RS15535 Protein ID WP_000415584.1
Coordinates 3178884..3179180 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NR351_RS15530 Protein ID WP_000650107.1
Coordinates 3178487..3178882 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS15520 (3174351) 3174351..3176609 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
NR351_RS15525 (3176747) 3176747..3178354 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NR351_RS15530 (3178487) 3178487..3178882 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NR351_RS15535 (3178884) 3178884..3179180 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NR351_RS15540 (3179385) 3179385..3179867 - 483 WP_000183505.1 GyrI-like domain-containing protein -
NR351_RS15545 (3179920) 3179920..3180312 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NR351_RS15550 (3180464) 3180464..3181123 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
NR351_RS15555 (3181120) 3181120..3182469 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NR351_RS15560 (3182515) 3182515..3182847 - 333 WP_000917684.1 DUF2645 family protein -
NR351_RS15565 (3183166) 3183166..3183747 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NR351_RS15570 (3183778) 3183778..3184092 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T253517 WP_000415584.1 NZ_CP102378:c3179180-3178884 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT253517 WP_000650107.1 NZ_CP102378:c3178882-3178487 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References