Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3751712..3752406 Replicon chromosome
Accession NZ_CP102374
Organism Pseudomonas sp. T8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NRG23_RS16800 Protein ID WP_053268076.1
Coordinates 3752110..3752406 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A554PLA7
Locus tag NRG23_RS16795 Protein ID WP_009046631.1
Coordinates 3751712..3752113 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRG23_RS16785 (NRG23_16785) 3746846..3750196 + 3351 WP_009046633.1 mechanosensitive channel MscK -
NRG23_RS16790 (NRG23_16790) 3750245..3751708 + 1464 WP_103330901.1 YdiU family protein -
NRG23_RS16795 (NRG23_16795) 3751712..3752113 - 402 WP_009046631.1 transcriptional regulator Antitoxin
NRG23_RS16800 (NRG23_16800) 3752110..3752406 - 297 WP_053268076.1 type II toxin-antitoxin system HigB family toxin Toxin
NRG23_RS16805 (NRG23_16805) 3752646..3753080 + 435 WP_016704469.1 thioredoxin TrxC -
NRG23_RS16810 (NRG23_16810) 3753206..3753976 - 771 WP_257371442.1 ParA family protein -
NRG23_RS16815 (NRG23_16815) 3754310..3755041 + 732 WP_036985559.1 beta-ketoacyl synthase chain length factor -
NRG23_RS16820 (NRG23_16820) 3755017..3755832 + 816 WP_016704468.1 lysophospholipid acyltransferase family protein -
NRG23_RS16825 (NRG23_16825) 3755807..3756067 + 261 WP_007926834.1 phosphopantetheine-binding protein -
NRG23_RS16830 (NRG23_16830) 3756077..3756331 + 255 WP_007926835.1 acyl carrier protein -
NRG23_RS16835 (NRG23_16835) 3756328..3756873 + 546 WP_009046626.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11588.41 Da        Isoelectric Point: 10.6515

>T253485 WP_053268076.1 NZ_CP102374:c3752406-3752110 [Pseudomonas sp. T8]
MHIITAKRIWEAKSRWPQSANALETWYRKVKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14840.85 Da        Isoelectric Point: 4.4394

>AT253485 WP_009046631.1 NZ_CP102374:c3752113-3751712 [Pseudomonas sp. T8]
MNVLVKQAADHWHFVAPVLRKPNTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554PLA7

References