Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 690933..691465 Replicon chromosome
Accession NC_015602
Organism Lactobacillus kefiranofaciens ZW3

Toxin (Protein)


Gene name yoeB Uniprot ID A0A656YA18
Locus tag WANG_RS03490 Protein ID WP_013854119.1
Coordinates 690933..691202 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A656Y9W5
Locus tag WANG_RS03495 Protein ID WP_013854120.1
Coordinates 691199..691465 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WANG_RS03465 685939..686568 - 630 WP_013854114.1 Crp/Fnr family transcriptional regulator -
WANG_RS03470 686587..687138 - 552 WP_013854115.1 DNA-binding protein -
WANG_RS03475 687138..687368 - 231 WP_013854116.1 cation transporter -
WANG_RS03480 687391..689292 - 1902 WP_013854117.1 heavy metal translocating P-type ATPase -
WANG_RS03485 689410..690747 - 1338 WP_025084196.1 MATE family efflux transporter -
WANG_RS03490 690933..691202 - 270 WP_013854119.1 Txe/YoeB family addiction module toxin Toxin
WANG_RS03495 691199..691465 - 267 WP_013854120.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WANG_RS03505 691716..692579 - 864 WP_025084193.1 alpha/beta hydrolase -
WANG_RS03510 692576..693745 - 1170 WP_013854123.1 pyridoxal phosphate-dependent aminotransferase -
WANG_RS03515 693751..694644 - 894 WP_013854124.1 DUF3737 family protein -
WANG_RS03520 694703..695020 - 318 WP_025084192.1 carboxymuconolactone decarboxylase family protein -
WANG_RS03525 695030..695445 - 416 Protein_675 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10617.35 Da        Isoelectric Point: 10.4670

>T25348 WP_013854119.1 NC_015602:c691202-690933 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
MILKYHGRIKNSAKPDLKKIKRSNLKDNFQDIIDQLKKDPYKKNQGFEKLEPPILGKYSRRINIKHRVVYTVDDVNKIVS
IYSAWSHYE

Download         Length: 270 bp

>T25348 NC_015602:c691202-690933 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
ATGATTTTAAAATATCATGGCAGGATTAAAAACTCAGCTAAGCCTGATTTAAAGAAGATTAAGCGAAGTAATCTGAAAGA
TAATTTTCAAGATATTATAGATCAACTCAAAAAAGATCCTTATAAAAAGAATCAAGGATTTGAAAAATTAGAACCACCAA
TTTTAGGAAAATATTCTCGAAGAATCAATATAAAACATCGAGTTGTTTATACTGTTGATGATGTTAATAAGATAGTAAGT
ATTTACTCGGCCTGGTCACATTATGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9984.05 Da        Isoelectric Point: 4.4857

>AT25348 WP_013854120.1 NC_015602:c691465-691199 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
MDATIYTPTGARRNLFNLIKQVNKNHTPVNIESTKDKAESAVLISKSDWDAIQETLYLESNGVGEVVRKREKDNSGFTDI
DDINWDEL

Download         Length: 267 bp

>AT25348 NC_015602:c691465-691199 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
ATGGATGCAACAATTTATACTCCCACAGGAGCAAGACGTAATTTATTCAATCTTATCAAGCAAGTTAATAAAAACCATAC
TCCAGTTAATATTGAATCTACAAAAGATAAAGCAGAAAGTGCTGTGTTAATAAGTAAATCCGACTGGGACGCTATTCAGG
AGACTCTTTATCTTGAGTCCAATGGTGTAGGAGAAGTTGTGAGAAAACGTGAAAAGGACAATTCAGGTTTTACTGATATT
GATGATATTAACTGGGATGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656YA18

Antitoxin

Source ID Structure
AlphaFold DB A0A656Y9W5

References