Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2197331..2197845 Replicon chromosome
Accession NZ_CP102359
Organism Streptomyces sp. B146

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6G9ES44
Locus tag M6G09_RS09420 Protein ID WP_031030578.1
Coordinates 2197591..2197845 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6G9ESD1
Locus tag M6G09_RS09415 Protein ID WP_031030581.1
Coordinates 2197331..2197594 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G09_RS09405 (M6G09_09430) 2193078..2193938 + 861 WP_277723614.1 phosphatase PAP2 family protein -
M6G09_RS09410 (M6G09_09435) 2194168..2197179 - 3012 WP_277723615.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
M6G09_RS09415 (M6G09_09440) 2197331..2197594 + 264 WP_031030581.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M6G09_RS09420 (M6G09_09445) 2197591..2197845 + 255 WP_031030578.1 Txe/YoeB family addiction module toxin Toxin
M6G09_RS09425 (M6G09_09450) 2197930..2198376 + 447 WP_194277962.1 VOC family protein -
M6G09_RS09430 (M6G09_09455) 2198404..2200176 - 1773 WP_277723616.1 NAD+ synthase -
M6G09_RS09435 (M6G09_09460) 2200336..2200965 - 630 WP_194277960.1 DUF305 domain-containing protein -
M6G09_RS09440 (M6G09_09465) 2200962..2201630 - 669 WP_194277959.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9911.23 Da        Isoelectric Point: 9.7377

>T253478 WP_031030578.1 NZ_CP102359:2197591-2197845 [Streptomyces sp. B146]
VRVTFTSHGWEDYVHWAESDRKVTKRINRLIDDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADGVLVIVQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9784.92 Da        Isoelectric Point: 4.8784

>AT253478 WP_031030581.1 NZ_CP102359:2197331-2197594 [Streptomyces sp. B146]
MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9ES44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9ESD1

References