Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4858249..4858851 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NQZ80_RS23115 Protein ID WP_024046152.1
Coordinates 4858540..4858851 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQZ80_RS23110 Protein ID WP_000356395.1
Coordinates 4858249..4858539 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS23075 (4853873) 4853873..4854775 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NQZ80_RS23080 (4854772) 4854772..4855407 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NQZ80_RS23085 (4855404) 4855404..4856333 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NQZ80_RS23090 (4856515) 4856515..4856757 - 243 WP_001309881.1 CopG family transcriptional regulator -
NQZ80_RS23095 (4856976) 4856976..4857194 - 219 WP_001295676.1 CopG family transcriptional regulator -
NQZ80_RS23100 (4857613) 4857613..4857891 - 279 WP_001315112.1 hypothetical protein -
NQZ80_RS23105 (4857943) 4857943..4858164 - 222 WP_001550354.1 hypothetical protein -
NQZ80_RS23110 (4858249) 4858249..4858539 - 291 WP_000356395.1 NadS family protein Antitoxin
NQZ80_RS23115 (4858540) 4858540..4858851 - 312 WP_024046152.1 hypothetical protein Toxin
NQZ80_RS23120 (4859080) 4859080..4859988 + 909 WP_001550353.1 alpha/beta hydrolase -
NQZ80_RS23125 (4860156) 4860156..4861070 - 915 WP_198443813.1 transposase -
NQZ80_RS23130 (4861083) 4861083..4861970 - 888 Protein_4521 hypothetical protein -
NQZ80_RS23135 (4862386) 4862386..4863327 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NQZ80_RS23140 (4863372) 4863372..4863809 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12130.16 Da        Isoelectric Point: 9.5486

>T253372 WP_024046152.1 NZ_CP102244:c4858851-4858540 [Escherichia coli O7:H15]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHCEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT253372 WP_000356395.1 NZ_CP102244:c4858539-4858249 [Escherichia coli O7:H15]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References