Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1961987..1962489 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag NQZ80_RS09380 Protein ID WP_000767820.1
Coordinates 1962235..1962489 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NQZ80_RS09375 Protein ID WP_001259255.1
Coordinates 1961987..1962238 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS09350 (1957165) 1957165..1958232 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NQZ80_RS09355 (1958232) 1958232..1959302 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
NQZ80_RS09360 (1959299) 1959299..1960603 - 1305 WP_001578572.1 histidinol dehydrogenase -
NQZ80_RS09365 (1960609) 1960609..1961508 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NQZ80_RS09370 (1961654) 1961654..1961704 - 51 WP_001364200.1 his operon leader peptide -
NQZ80_RS09375 (1961987) 1961987..1962238 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NQZ80_RS09380 (1962235) 1962235..1962489 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NQZ80_RS09385 (1962572) 1962572..1963396 + 825 WP_000754756.1 SDR family oxidoreductase -
NQZ80_RS09390 (1963442) 1963442..1964371 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NQZ80_RS09395 (1964586) 1964586..1964648 + 63 WP_010723108.1 membrane protein YoeI -
NQZ80_RS09400 (1964638) 1964638..1965996 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NQZ80_RS09405 (1966175) 1966175..1967233 + 1059 WP_001759318.1 thiosulfate utilization transporter TsuA/YeeE -
NQZ80_RS09410 (1967247) 1967247..1967474 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T253358 WP_000767820.1 NZ_CP102244:1962235-1962489 [Escherichia coli O7:H15]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT253358 WP_001259255.1 NZ_CP102244:1961987-1962238 [Escherichia coli O7:H15]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References