253351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1248964..1249504 Replicon chromosome
Accession NZ_CP102197
Organism Schaalia odontolytica strain KHUD_008

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NQK35_RS05510 Protein ID WP_257114773.1
Coordinates 1249259..1249504 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQK35_RS05505 Protein ID WP_257113368.1
Coordinates 1248964..1249227 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK35_RS05490 (NQK35_05490) 1245565..1246269 - 705 WP_257113363.1 type I restriction-modification system subunit M -
NQK35_RS05495 (NQK35_05495) 1246361..1247446 - 1086 WP_257113365.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
NQK35_RS05500 (NQK35_05500) 1247413..1248825 - 1413 WP_257113367.1 AAA family ATPase -
NQK35_RS05505 (NQK35_05505) 1248964..1249227 - 264 WP_257113368.1 HigA family addiction module antitoxin Antitoxin
NQK35_RS05510 (NQK35_05510) 1249259..1249504 - 246 WP_257114773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQK35_RS05515 (NQK35_05515) 1249690..1250772 - 1083 WP_257113369.1 redox-regulated ATPase YchF -
NQK35_RS05520 (NQK35_05520) 1250810..1251877 - 1068 WP_034232405.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
NQK35_RS05525 (NQK35_05525) 1251995..1253293 + 1299 WP_257113372.1 exodeoxyribonuclease VII large subunit -
NQK35_RS05530 (NQK35_05530) 1253335..1253565 + 231 WP_009213349.1 exodeoxyribonuclease VII small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-81)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-81)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9453.85 Da        Isoelectric Point: 9.9992

>T253351 WP_257114773.1 NZ_CP102197:c1249504-1249259 [Schaalia odontolytica]
MFAREPVPSLDSRIIRVALRKLRQIDAACHLDDLRIPPGNRLERLRGNRAGRYSIRINDQWRICFRWGDAGPEGVEVVDY
H

Download         Length: 246 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9641.14 Da        Isoelectric Point: 7.2011

>AT253351 WP_257113368.1 NZ_CP102197:c1249227-1248964 [Schaalia odontolytica]
MEDFIKGYGITQHKLAVAIGVPPRRINEVVHGKRGITADTAMRLSRYFGTTAGFWMNLQMRYELDRAEDTMGETLSGIVP
LAAVEVA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References