Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1490..2217 | Replicon | plasmid pS270V-1 |
| Accession | NZ_CP102193 | ||
| Organism | Klebsiella pneumoniae strain S270v | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | NQZ65_RS26480 | Protein ID | WP_011251285.1 |
| Coordinates | 1490..1801 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NQZ65_RS26485 | Protein ID | WP_011251286.1 |
| Coordinates | 1798..2217 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ65_RS26475 (NQZ65_26480) | 848..1285 | + | 438 | Protein_1 | DDE-type integrase/transposase/recombinase | - |
| NQZ65_RS26480 (NQZ65_26485) | 1490..1801 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NQZ65_RS26485 (NQZ65_26490) | 1798..2217 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NQZ65_RS26490 (NQZ65_26495) | 2364..3332 | + | 969 | WP_074428168.1 | IS5 family transposase | - |
| NQZ65_RS26495 (NQZ65_26500) | 3404..3769 | - | 366 | WP_048333448.1 | hypothetical protein | - |
| NQZ65_RS26500 (NQZ65_26505) | 3783..4571 | - | 789 | WP_040217257.1 | hypothetical protein | - |
| NQZ65_RS26505 (NQZ65_26510) | 4592..5212 | - | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| NQZ65_RS26510 (NQZ65_26515) | 5631..6266 | + | 636 | WP_227661578.1 | hypothetical protein | - |
| NQZ65_RS26515 (NQZ65_26520) | 6579..7049 | + | 471 | WP_048333570.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / rmpA / iroN | 1..221246 | 221246 | |
| - | inside | IScluster/Tn | - | - | 16..18888 | 18872 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T253338 WP_011251285.1 NZ_CP102193:1490-1801 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT253338 WP_011251286.1 NZ_CP102193:1798-2217 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|