Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1490..2217 Replicon plasmid pS270V-1
Accession NZ_CP102193
Organism Klebsiella pneumoniae strain S270v

Toxin (Protein)


Gene name higB Uniprot ID A0A7W3D9W1
Locus tag NQZ65_RS26480 Protein ID WP_011251285.1
Coordinates 1490..1801 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQZ65_RS26485 Protein ID WP_011251286.1
Coordinates 1798..2217 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ65_RS26475 (NQZ65_26480) 848..1285 + 438 Protein_1 DDE-type integrase/transposase/recombinase -
NQZ65_RS26480 (NQZ65_26485) 1490..1801 + 312 WP_011251285.1 type II toxin-antitoxin system HigB family toxin Toxin
NQZ65_RS26485 (NQZ65_26490) 1798..2217 + 420 WP_011251286.1 helix-turn-helix domain-containing protein Antitoxin
NQZ65_RS26490 (NQZ65_26495) 2364..3332 + 969 WP_074428168.1 IS5 family transposase -
NQZ65_RS26495 (NQZ65_26500) 3404..3769 - 366 WP_048333448.1 hypothetical protein -
NQZ65_RS26500 (NQZ65_26505) 3783..4571 - 789 WP_040217257.1 hypothetical protein -
NQZ65_RS26505 (NQZ65_26510) 4592..5212 - 621 WP_223175004.1 conjugative transfer protein MobI(A/C) -
NQZ65_RS26510 (NQZ65_26515) 5631..6266 + 636 WP_227661578.1 hypothetical protein -
NQZ65_RS26515 (NQZ65_26520) 6579..7049 + 471 WP_048333570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / rmpA / iroN 1..221246 221246
- inside IScluster/Tn - - 16..18888 18872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12346.12 Da        Isoelectric Point: 9.7248

>T253338 WP_011251285.1 NZ_CP102193:1490-1801 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15377.46 Da        Isoelectric Point: 4.4420

>AT253338 WP_011251286.1 NZ_CP102193:1798-2217 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3D9W1

Antitoxin

Source ID Structure

References