Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 17158..17885 | Replicon | plasmid pS234-1 |
| Accession | NZ_CP102187 | ||
| Organism | Klebsiella pneumoniae strain S234 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | NQZ63_RS26850 | Protein ID | WP_011251285.1 |
| Coordinates | 17158..17469 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NQZ63_RS26855 | Protein ID | WP_011251286.1 |
| Coordinates | 17466..17885 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ63_RS26810 (NQZ63_26810) | 12169..12663 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| NQZ63_RS26815 (NQZ63_26815) | 12669..13109 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| NQZ63_RS26820 (NQZ63_26820) | 13534..14490 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| NQZ63_RS26825 (NQZ63_26825) | 14550..14891 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| NQZ63_RS26830 (NQZ63_26830) | 14905..15216 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| NQZ63_RS26835 (NQZ63_26835) | 15233..15682 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| NQZ63_RS26845 (NQZ63_26845) | 16516..16953 | + | 438 | Protein_21 | DDE-type integrase/transposase/recombinase | - |
| NQZ63_RS26850 (NQZ63_26850) | 17158..17469 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NQZ63_RS26855 (NQZ63_26855) | 17466..17885 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NQZ63_RS26860 (NQZ63_26860) | 18032..19000 | + | 969 | WP_074428168.1 | IS5 family transposase | - |
| NQZ63_RS26865 (NQZ63_26865) | 19072..19437 | - | 366 | WP_048333448.1 | hypothetical protein | - |
| NQZ63_RS26870 (NQZ63_26870) | 19451..20239 | - | 789 | WP_040217257.1 | hypothetical protein | - |
| NQZ63_RS26875 (NQZ63_26875) | 20260..20880 | - | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| NQZ63_RS26880 (NQZ63_26880) | 21299..21934 | + | 636 | WP_227661578.1 | hypothetical protein | - |
| NQZ63_RS26885 (NQZ63_26885) | 22247..22717 | + | 471 | WP_048333570.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN | 1..219806 | 219806 | |
| - | inside | IScluster/Tn | - | - | 10249..34556 | 24307 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T253310 WP_011251285.1 NZ_CP102187:17158-17469 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT253310 WP_011251286.1 NZ_CP102187:17466-17885 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|