Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5626643..5627312 Replicon chromosome
Accession NZ_CP102175
Organism Pseudomonas corrugata strain B21-061

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY65_RS24800 Protein ID WP_055136377.1
Coordinates 5626947..5627312 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3M3EAW2
Locus tag LOY65_RS24795 Protein ID WP_024779393.1
Coordinates 5626643..5626954 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY65_RS24785 (LOY65_24790) 5622226..5625273 - 3048 WP_265075431.1 DEAD/DEAH box helicase -
LOY65_RS24790 (LOY65_24795) 5625278..5626111 - 834 WP_265075432.1 DUF1837 domain-containing protein -
LOY65_RS24795 (LOY65_24800) 5626643..5626954 - 312 WP_024779393.1 XRE family transcriptional regulator Antitoxin
LOY65_RS24800 (LOY65_24805) 5626947..5627312 - 366 WP_055136377.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY65_RS24805 (LOY65_24810) 5627596..5629959 + 2364 WP_265068324.1 hypothetical protein -
LOY65_RS24810 (LOY65_24815) 5629996..5630457 + 462 WP_024779396.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5606830..5635347 28517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(5-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14038.73 Da        Isoelectric Point: 5.5787

>T253275 WP_055136377.1 NZ_CP102175:c5627312-5626947 [Pseudomonas corrugata]
MKWDVEYTDEFEIWWNRLGESEQDSVQASVMLLGDAGPFLGFPHTSDIKGSRHGNLRELRVQHGGRPYRVLYAFDPRRCA
ILLIGGGKTGQDRWYHEYVPLAERLYDEHLEVLKKEGFDNG

Download         Length: 366 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11825.59 Da        Isoelectric Point: 9.9873

>AT253275 WP_024779393.1 NZ_CP102175:c5626954-5626643 [Pseudomonas corrugata]
MAKKFADLVARRSPDSQVRTQALYQKLRAEMPLHELRQAQELSQEALAKALHINQAAVSKMERRTDMYISTLRNYIRAMG
GELEIIATFPDGQVRIENFSHQP

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3EAW2

References