Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5848440..5849035 Replicon chromosome
Accession NZ_CP102174
Organism Pseudomonas aeruginosa strain PA5083

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NQ602_RS27380 Protein ID WP_003113526.1
Coordinates 5848757..5849035 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQ602_RS27375 Protein ID WP_003133769.1
Coordinates 5848440..5848745 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ602_RS27360 (NQ602_27360) 5845146..5846009 - 864 WP_031761182.1 integrase domain-containing protein -
NQ602_RS27365 (NQ602_27365) 5846610..5847767 - 1158 WP_031761183.1 STY4528 family pathogenicity island replication protein -
NQ602_RS27375 (NQ602_27375) 5848440..5848745 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
NQ602_RS27380 (NQ602_27380) 5848757..5849035 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQ602_RS27385 (NQ602_27385) 5849088..5849216 - 129 Protein_5413 integrase -
NQ602_RS27390 (NQ602_27390) 5849364..5851592 + 2229 WP_023104079.1 TonB-dependent receptor -
NQ602_RS27395 (NQ602_27395) 5851663..5852310 - 648 WP_003095021.1 carbonate dehydratase -
NQ602_RS27400 (NQ602_27400) 5852372..5853610 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T253272 WP_003113526.1 NZ_CP102174:c5849035-5848757 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT253272 WP_003133769.1 NZ_CP102174:c5848745-5848440 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References