Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2013294..2013813 Replicon chromosome
Accession NZ_CP102148
Organism Streptococcus suis strain DNC15

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8MQK4
Locus tag NQZ90_RS09745 Protein ID WP_024383250.1
Coordinates 2013294..2013551 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag NQZ90_RS09750 Protein ID WP_029693536.1
Coordinates 2013553..2013813 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ90_RS09730 (NQZ90_09730) 2009925..2011655 - 1731 WP_203200624.1 hypothetical protein -
NQZ90_RS09735 (NQZ90_09735) 2011858..2012730 - 873 WP_105155307.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ90_RS09740 (NQZ90_09740) 2012751..2013280 - 530 Protein_1881 DUF1697 domain-containing protein -
NQZ90_RS09745 (NQZ90_09745) 2013294..2013551 - 258 WP_024383250.1 Txe/YoeB family addiction module toxin Toxin
NQZ90_RS09750 (NQZ90_09750) 2013553..2013813 - 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ90_RS09755 (NQZ90_09755) 2013889..2014344 - 456 WP_044676156.1 8-oxo-dGTP diphosphatase -
NQZ90_RS09760 (NQZ90_09760) 2014348..2014716 - 369 WP_105155306.1 hypothetical protein -
NQZ90_RS09765 (NQZ90_09765) 2014709..2015278 - 570 WP_105155305.1 ribonuclease M5 -
NQZ90_RS09770 (NQZ90_09770) 2015262..2016044 - 783 WP_024407321.1 TatD family hydrolase -
NQZ90_RS09775 (NQZ90_09775) 2016151..2016288 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ90_RS09780 (NQZ90_09780) 2016456..2017451 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ90_RS09785 (NQZ90_09785) 2017471..2018283 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NQZ90_RS09790 (NQZ90_09790) 2018267..2018626 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10293.77 Da        Isoelectric Point: 7.3119

>T253249 WP_024383250.1 NZ_CP102148:c2013551-2013294 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADKLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT253249 WP_029693536.1 NZ_CP102148:c2013813-2013553 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8MQK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References