253246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 713092..713746 Replicon chromosome
Accession NZ_CP102148
Organism Streptococcus suis strain DNC15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NQZ90_RS03465 Protein ID WP_257110357.1
Coordinates 713092..713457 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G7SDV1
Locus tag NQZ90_RS03470 Protein ID WP_014637767.1
Coordinates 713447..713746 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ90_RS03450 (NQZ90_03450) 709282..709875 - 594 WP_105155429.1 DUF1361 domain-containing protein -
NQZ90_RS03455 (NQZ90_03455) 710031..712034 + 2004 WP_044685961.1 methionine--tRNA ligase -
NQZ90_RS03460 (NQZ90_03460) 712095..713048 + 954 WP_044669863.1 competence protein CoiA family protein -
NQZ90_RS03465 (NQZ90_03465) 713092..713457 + 366 WP_257110357.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ90_RS03470 (NQZ90_03470) 713447..713746 + 300 WP_014637767.1 helix-turn-helix transcriptional regulator Antitoxin
NQZ90_RS03475 (NQZ90_03475) 713856..715658 + 1803 WP_024389335.1 oligoendopeptidase F -
NQZ90_RS03480 (NQZ90_03480) 715660..716103 + 444 WP_024389334.1 hypothetical protein -
NQZ90_RS03485 (NQZ90_03485) 716114..716662 + 549 WP_024389333.1 hypothetical protein -
NQZ90_RS03490 (NQZ90_03490) 716737..717456 + 720 WP_044669888.1 O-methyltransferase -
NQZ90_RS03495 (NQZ90_03495) 717518..718501 + 984 WP_014637772.1 peptidylprolyl isomerase PrsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14507.73 Da        Isoelectric Point: 10.0120

>T253246 WP_257110357.1 NZ_CP102148:713092-713457 [Streptococcus suis]
MYTIYFYKDKNGREPVLEYLRELASKKEKDSRIKLNKINDYIELLSQLGTQIGEPYVKHLEGNIWELRPLRDRILFVAWY
DGSFVLLHHFVKRSQKTPRRELEKAQRELADLKERGINNGK

Download         Length: 366 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11058.73 Da        Isoelectric Point: 7.2059

>AT253246 WP_014637767.1 NZ_CP102148:713447-713746 [Streptococcus suis]
MENSAIGSNWQSVRSELFSEKEIIESDLRVAIMSELIKARHEQGVSQKRLEELSGVSQPVIARMETGKTSPQLDTILKVL
ASLGKTLAVVPLKQERHFQ

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G7SDV1

References