Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2056391..2056910 Replicon chromosome
Accession NZ_CP102143
Organism Streptococcus suis strain DNR43

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NQZ92_RS10350 Protein ID WP_013730620.1
Coordinates 2056391..2056648 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NQZ92_RS10355 Protein ID WP_002939010.1
Coordinates 2056650..2056910 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ92_RS10335 (NQZ92_10335) 2052862..2054592 - 1731 WP_009910905.1 membrane protein -
NQZ92_RS10340 (NQZ92_10340) 2054955..2055827 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ92_RS10345 (NQZ92_10345) 2055847..2056377 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NQZ92_RS10350 (NQZ92_10350) 2056391..2056648 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NQZ92_RS10355 (NQZ92_10355) 2056650..2056910 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ92_RS10360 (NQZ92_10360) 2056986..2057441 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
NQZ92_RS10365 (NQZ92_10365) 2057445..2057813 - 369 WP_013730622.1 hypothetical protein -
NQZ92_RS10370 (NQZ92_10370) 2057806..2058375 - 570 WP_022540720.1 ribonuclease M5 -
NQZ92_RS10375 (NQZ92_10375) 2058359..2059141 - 783 WP_002939015.1 TatD family hydrolase -
NQZ92_RS10380 (NQZ92_10380) 2059249..2059386 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ92_RS10385 (NQZ92_10385) 2059554..2060549 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ92_RS10390 (NQZ92_10390) 2060569..2061381 - 813 WP_226960674.1 YidC/Oxa1 family membrane protein insertase -
NQZ92_RS10395 (NQZ92_10395) 2061365..2061724 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T253238 WP_013730620.1 NZ_CP102143:c2056648-2056391 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT253238 WP_002939010.1 NZ_CP102143:c2056910-2056650 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References