Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2046298..2046817 Replicon chromosome
Accession NZ_CP102141
Organism Streptococcus suis strain DNR48

Toxin (Protein)


Gene name yoeB Uniprot ID A0A075SJE9
Locus tag NQZ93_RS10200 Protein ID WP_024381174.1
Coordinates 2046298..2046555 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag NQZ93_RS10205 Protein ID WP_029693774.1
Coordinates 2046557..2046817 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ93_RS10185 (NQZ93_10185) 2042770..2044500 - 1731 WP_024381172.1 membrane protein -
NQZ93_RS10190 (NQZ93_10190) 2044862..2045734 - 873 WP_002939007.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ93_RS10195 (NQZ93_10195) 2045754..2046284 - 531 WP_024381173.1 DUF1697 domain-containing protein -
NQZ93_RS10200 (NQZ93_10200) 2046298..2046555 - 258 WP_024381174.1 Txe/YoeB family addiction module toxin Toxin
NQZ93_RS10205 (NQZ93_10205) 2046557..2046817 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ93_RS10210 (NQZ93_10210) 2046893..2047270 - 378 WP_257115279.1 8-oxo-dGTP diphosphatase -
NQZ93_RS10215 (NQZ93_10215) 2047314..2048762 - 1449 WP_012775555.1 recombinase family protein -
NQZ93_RS10220 (NQZ93_10220) 2048755..2050374 - 1620 WP_012775554.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(O) - 2033353..2081741 48388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10392.94 Da        Isoelectric Point: 8.0279

>T253229 WP_024381174.1 NZ_CP102141:c2046555-2046298 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMMEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT253229 WP_029693774.1 NZ_CP102141:c2046817-2046557 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075SJE9

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References