Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1965941..1966460 Replicon chromosome
Accession NZ_CP102140
Organism Streptococcus suis strain DNC49

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NQZ94_RS09830 Protein ID WP_013730620.1
Coordinates 1965941..1966198 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NQZ94_RS09835 Protein ID WP_002939010.1
Coordinates 1966200..1966460 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ94_RS09815 (NQZ94_09815) 1962412..1964142 - 1731 WP_009910905.1 membrane protein -
NQZ94_RS09820 (NQZ94_09820) 1964505..1965377 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ94_RS09825 (NQZ94_09825) 1965397..1965927 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NQZ94_RS09830 (NQZ94_09830) 1965941..1966198 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NQZ94_RS09835 (NQZ94_09835) 1966200..1966460 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ94_RS09840 (NQZ94_09840) 1966536..1966991 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
NQZ94_RS09845 (NQZ94_09845) 1966995..1967363 - 369 WP_013730622.1 hypothetical protein -
NQZ94_RS09850 (NQZ94_09850) 1967356..1967925 - 570 WP_022540720.1 ribonuclease M5 -
NQZ94_RS09855 (NQZ94_09855) 1967909..1968691 - 783 WP_002939015.1 TatD family hydrolase -
NQZ94_RS09860 (NQZ94_09860) 1968799..1968936 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ94_RS09865 (NQZ94_09865) 1969104..1970099 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ94_RS09870 (NQZ94_09870) 1970119..1970931 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
NQZ94_RS09875 (NQZ94_09875) 1970915..1971274 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T253225 WP_013730620.1 NZ_CP102140:c1966198-1965941 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT253225 WP_002939010.1 NZ_CP102140:c1966460-1966200 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References