Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2015786..2016305 Replicon chromosome
Accession NZ_CP102135
Organism Streptococcus suis strain M106471_S40

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4T2GMW4
Locus tag NQZ98_RS10180 Protein ID WP_027974104.1
Coordinates 2015786..2016043 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag NQZ98_RS10185 Protein ID WP_029693536.1
Coordinates 2016045..2016305 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ98_RS10170 (NQZ98_10170) 2012704..2014434 - 1731 WP_171997155.1 hypothetical protein -
NQZ98_RS10175 (NQZ98_10175) 2014798..2015670 - 873 WP_171997154.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ98_RS10180 (NQZ98_10180) 2015786..2016043 - 258 WP_027974104.1 Txe/YoeB family addiction module toxin Toxin
NQZ98_RS10185 (NQZ98_10185) 2016045..2016305 - 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ98_RS10190 (NQZ98_10190) 2016381..2016836 - 456 WP_044676156.1 8-oxo-dGTP diphosphatase -
NQZ98_RS10195 (NQZ98_10195) 2016840..2017208 - 369 WP_044676157.1 hypothetical protein -
NQZ98_RS10200 (NQZ98_10200) 2017201..2017770 - 570 WP_044685609.1 ribonuclease M5 -
NQZ98_RS10205 (NQZ98_10205) 2017754..2018536 - 783 WP_024408020.1 TatD family hydrolase -
NQZ98_RS10210 (NQZ98_10210) 2018643..2018780 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ98_RS10215 (NQZ98_10215) 2018948..2019943 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ98_RS10220 (NQZ98_10220) 2019963..2020775 - 813 WP_172039798.1 YidC/Oxa1 family membrane protein insertase -
NQZ98_RS10225 (NQZ98_10225) 2020759..2021118 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10293.73 Da        Isoelectric Point: 6.7247

>T253203 WP_027974104.1 NZ_CP102135:c2016043-2015786 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADQLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT253203 WP_029693536.1 NZ_CP102135:c2016305-2016045 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4T2GMW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References