Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1082068..1082701 Replicon chromosome
Accession NZ_CP102097
Organism Vibrio japonicus strain JCM 31412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NP165_RS18260 Protein ID WP_140139435.1
Coordinates 1082369..1082701 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP165_RS18255 Protein ID WP_140139434.1
Coordinates 1082068..1082382 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP165_RS18230 (NP165_18230) 1077725..1077814 + 90 WP_074190930.1 DUF3265 domain-containing protein -
NP165_RS18235 (NP165_18235) 1078109..1079062 - 954 WP_257085860.1 IS1595 family transposase -
NP165_RS18240 (NP165_18240) 1079404..1080315 - 912 WP_248419187.1 toll/interleukin-1 receptor domain-containing protein -
NP165_RS18245 (NP165_18245) 1080580..1080972 + 393 WP_257085886.1 hypothetical protein -
NP165_RS18250 (NP165_18250) 1081115..1081399 - 285 WP_257085885.1 hypothetical protein -
NP165_RS18255 (NP165_18255) 1082068..1082382 - 315 WP_140139434.1 DNA-binding transcriptional regulator Antitoxin
NP165_RS18260 (NP165_18260) 1082369..1082701 - 333 WP_140139435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP165_RS18265 (NP165_18265) 1083497..1083709 - 213 WP_025553613.1 hypothetical protein -
NP165_RS18270 (NP165_18270) 1083971..1084924 + 954 WP_257085860.1 IS1595 family transposase -
NP165_RS18275 (NP165_18275) 1085433..1085930 - 498 WP_011080392.1 GNAT family N-acetyltransferase -
NP165_RS18280 (NP165_18280) 1085927..1086199 - 273 WP_257085896.1 DUF1778 domain-containing protein -
NP165_RS18285 (NP165_18285) 1086373..1087332 + 960 WP_257085897.1 IS1595 family transposase -
NP165_RS18290 (NP165_18290) 1087350..1087610 + 261 WP_257085898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1078109..1091425 13316
- inside Integron - - 1009525..1078214 68689
- inside Integron - - 1079284..1084924 5640
- inside Integron - - 1085285..1088282 2997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-104)

Antitoxin

Antitoxin MqsA/HigA-2

(25-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12893.76 Da        Isoelectric Point: 10.0960

>T253193 WP_140139435.1 NZ_CP102097:c1082701-1082369 [Vibrio japonicus]
MKSVFVESTIFEKYRSEYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11706.15 Da        Isoelectric Point: 6.3290

>AT253193 WP_140139434.1 NZ_CP102097:c1082382-1082068 [Vibrio japonicus]
MSNRDLFAELSSALTEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References